ABSTRACT
As one of the common endocrine diseases in children, the incidence of type 1 diabetes mellitus(T1DM)is increasing year by year.T1DM is an autoimmune disease.It is generally believed that the pathogenesis of T1DM is that the immune disorder of genetically susceptible individuals under the action of environmental factors causes immune damage, leading to islet inflammation and the production of autoantibodies, and the destruction of β cells of the islet, leading to insufficient insulin secretion to absolute deficiency.Although there is no effective radical cure for T1DM at present, more and more research on stem cell therapy has been conducted.Umbilical cord blood, as an important source of stem cells, is expected to make the radical cure of T1DM possible in the future.In this paper, the mechanism of immune injury in T1DM and the progress of umbilical cord blood stem cell therapy are reviewed.
ABSTRACT
Objective To investigate the functional mechanism of metformin in improving the fatty liver and the treatment of the relative metabolic abnormalities of type 2 diabetes mellitus.Methods The model of type 2 diabetes mellitus complicated with fatty liver was set up by feeding high-glucose-high-fat diet and by injecting STZ.Then,the rats were made an intervention with metformin.At the end of 4 weeks and 8 weeks,the fasting blood glucose,the level of fasting serum insulin.At the end of 18 weeks the fasting blood glucose,the level of fasting serum insulin,ALT,TNF-? and the level of leptin of every group of rats were measured and the expression of TNF-? in the liver was determined.Results Metformin could largely reduce the blood glucose,TG,TC and the fatty content of the liver,improve the state of the insulin resistance and reduce the expression level of the TNF-? in the liver.Conclusion Metformin can have the treatment functions to the rats with fatty liver in the model of type 2 diabetes mellitus complicated with fatty liver.